David Frank, M.D. Ph.D.
Dana Farber Cancer Institute
Harvard Medical School
Boston, MA
(866) 408-DFCI (3324)
http://www.dana-farber.org

Honors and Awards
1980 John Asinari Award for Research in the Biological Sciences
1981 Phi Beta Kappa
1985 Sigma Xi
1986 American Cancer Society Award for Research
1988 WintersTeaching Award
1988 Samuel D. Kushlan Award
1989 Steven Shell Memorial Award
1990 Winters Teaching Award
1990 Hugh Dwyer Memorial Award
1992-1995 Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians
1999 Fellow, Molecular Medicine Society
1999 Medical Student Teaching Award, Harvard Medical School
2000-2002 Rising Stars Discovery Fellowship
2002 Fellow, American College of Physicians
2002 Kittredge Research Award

Selected Publications
1. Bonni A, Frank DA, Schindler C, Greenberg ME. Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science 1993; 262: 1575-9.

2. Frank DA, Greenberg ME. CREB: A mediator of long term memory from mollusks to mammals. Cell 1994; 79:5-8.

3. Frank DA, Robertson M, Bonni A, Ritz J, Greenberg ME. IL-2 signaling involves the phosphorylation of novel stat proteins. Proc. Natl. Acad. Sci. 1995; 92: 7779 83.

4. Carlesso N, Frank DA, Griffin JD. Tyrosyl phosphorylation and DNA-binding activity of STAT proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med. 1996; 183: 811-20.

5. Frank DA, Varticovski L. BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia 1996; 10:1724-30.

6. Arbiser JL, Moses MA, Fernandez CA, Ghiso N, Cao Y, Klauber N, Frank D, Brownlee M, Flynn E, Parangi S, Byers HR, Folkman J. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc. Natl. Acad. Sci. 1997; 94:861-6.

7. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 1997; 278: 477-483.

8. Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain STAT1 and STAT3 constitutively phosphorylated on serine residues. J. Clin. Invest. 1997; 100: 3140-8.

9. Gollob JA, Murphy EA, Mahajan S, Schnipper CP, Ritz J, Frank DA. Altered IL 12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1. Blood 1998; 91: 1341-54.

10. Gollob JA, Schnipper CP, Orsini E, Murphy E, Daley JF, Lazo SB, Frank DA, Ritz J. Characterization of a novel subset of CD8+ T cells that expands in patients receiving interleukin-12. J. Clin. Inv. 1998; 102:561-75.

11. Wang K, Ritz J, Frank DA. IL-2 induces STAT4 activation in primary NK cells and NK cell lines but not in T cells. J. Immunol. 1999; 162:299-304.

12. Gollob JA, Murphy EA, Schnipper CP, Ritz J, Frank DA. The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. J. Immunol. 1999; 162:4472-4481.

13. Frank DA. STAT signaling in the pathogenesis and treatment of cancer. Mol. Med. 1999; 5:432-56.

14. Frank DA, Mahajan S, Ritz J. Fludarabine induces immunosuppression through the inhibition of STAT1 signaling. Nature Med. 1999; 5:444-7.

15. Turkson J, Bowman T, Adnane J, Zhang Y, Sekharm M, Frank DA, Holzman LB, Wu J, Sebti S, Jove R. Requirement of Rac1-mediated p38 and JNK signaling for Stat3 transcriptional activity induced by the Src oncoprotein. Mol. Cell. Biol. 1999; 19:7519-28.

16. Lin TS, Mahajan S, Frank DA. STAT signaling in the pathogenesis and treatment of leukemias. Oncogene 2000; 19:2496-504.

17. Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD. STAT5 activation contributes to growth and viability in Bcr/Abl transformed cells. Blood 2000; 95:2118-25.

18. Wang KS, Frank DA, Ritz J. IL-2 enhances the response of NK cells to IL-12 through upregulation of the IL-12 receptor and STAT4. Blood 2000; 95:3183-90.

19. Karras JG, McKay R, Lu T, Pych J, Frank DA, Rothstein TL, Monia, BP. STAT3 regulates cell growth, immunoglobulin production, and chemokine gene expression in a B lymphoma model of B-1 cells. Cell. Immunol. 2000; 202:124-35.

20. Gollob JA, Veenstra KG, Jyonouchi H, Panka DJ, Altare F, Casanova J-L, Frank DA, Wang K, Ritz J, Mier JW. Impairment of STAT activation by IL-12 in a patient with an atypical mycobacterial infection. J. Immunol. 2000; 165:4120-6.

21. Duarte RF, Frank DA. SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood 2000; 96:3422-30.

22. LaMontagne KR, Moses MA, Wiederschain D, Mahajan S, Holden J, Ghazizadeh H, Frank DA, Arbiser JL. Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells. Am. J. Pathol. 2000; 157:1937-45.

23. Mahajan S, Gollob JA, Ritz J, Frank DA. CD2 stimulation leads to the delayed and prolonged activation of STAT1 in T cells. Exp. Hematol. 2001; 29:209-20.

24. Barber DL, Beattie BK, Mason JM, Nguyen MH-H, Yoakim M, Neel BG, D’Andrea AD, Frank DA. A common epitope is shared by activated STAT5 and the phosphorylated erythropoietin receptor. Implications for the docking model of STAT activation. Blood 2001; 97:2230-7.

25. Vonderheide RH, Butler MO, Liu JF, Battle TE, Hirano N, Gribben JG, Frank DA, Schultze JL, Nadler LM. CD40-activation of carcinoma cells increases expression of adhesion and major histocompatibility molecules but fails to induce either CD80/CD86 expression or T cell alloreactivity. Int. J. Oncol. 2001; 19:791-8.

26. Boeuf H, Merienne K, Jacquot S, Duval D, Zeniou M, Hauss C, Reinhardt B, Huss Garcia Y, Dierich A, Frank DA, Hanauer A, Kedinger C. The RSKs, CREB, and STAT3 proteins are regulated by different LIF signaling pathways in mouse embryonic stem cells. J. Biol. Chem. 2001; 276:46204-46211.

27. Duarte R, Frank DA. The synergy between stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF): Molecular basis and clinical relevance. Leukem. Lymphom. 2002; 43:1179-87.

28. Battle TE, Frank DA. STATs in apoptosis. Curr. Mol. Med. 2002; 2:381-392.

29. Frank DA. STAT signaling in cancer: Insights into pathogenesis and treatment strategies. Cancer Treat. Res. 2003; in press.

30. Battle TE, Castro-Malaspina H, Gribben JG, Frank DA. Sustained complete remission of CLL associated with the use of a Chinese herbal extract: Case report and mechanistic analysis. Leukemia Res. 2003; in press.

31. Battle TE, Wierda WG, Rassenti LZ, Zahrieh D, Neuberg D, Kipps TJ, Frank DA. In vivo activation of STAT1 following CD154 gene therapy for chronic lymphocytic leukemia is associated with clinical and immunologic response. Clin. Cancer Res. 2003; in press.