CRC Trial

CRC clinical investigators are participating in the listed clinical trials. Site participation varies. In order to find out more about the clinical trials occurring at the CRC site nearest you, please contact a research site from the Quick Links section. The research nurses/coordinators will be able to assist you with the details of these clinical trials and others being conducted at each local site. What is a Clinical Trial?

Protocols:

Phase I/II Study of Oxaliplatin, Fludarabine, Cytarabine, and Rituximab in
Patients with Richter's Transformation, Prolymphocytic Leukimia or
Refractory /Relpsed B-Cell Chronic Lymphocytic Leukemia

Abstract

A Two-Arm, Multi-center trial of Revlimid® and Rituximab, for First-Line Treatment in Patients with B-cell Chronic Lymphocytic Leukemia (CLL) Brief Description: The study is a two-arm, multi-center trial of Revlimid® and Rituximab, for the frontline treatment of patients with Chronic Lymphocytic Leukemia (CLL) designed and conducted by the CLL Research Consoritum (CRC). The purpose of this study is to determine the response rate of the combination of Revlimid® and Rituximab in previously untreated CLL patients in two arms- those aged 65 years and above and those younger than 65. Secondary objectives will evaluate the safety of the combination of Revlimid® and Rituximab, response duration, improvement in hematologic parameters, and the prognostic role of the tumor flare reaction. All patients will have assessment of known prognostic factors for CLL as well as novel prognostic factors will be evaluated for predicting response to treatment. Biologic corollary studies are designed to evaluate the mechanism of Revlimid® in CLL and the combination of Revlimid® and Rituximab.

Abstract

CLL Research Consortium Tissue Core Sample Collection Study and Familial
Study Sample Collection

Abstract

Kinetic Biomarker for Chronic Lymphocytic Leukemia (CLL) Prognosis

Abstract

A Phase I Study of 8-Chloro-Adenosine in Previously Treated Patients with Chronic Lymphocytic Leukemia

Abstract

 

The Latest Clinical Trials at CRC Sites:

• Latest clinical trials at the Harvard University - Dana Farber Cancer Center
• Latest clinical trials at Long Island Jewish Medical Center
• Latest clinical trials at the Mayo Clinic
• Latest clinical trials at the Ohio State University - James Cancer Center
• Latest clinical trials at the University of California, San Diego - Rebecca and
  John Moores UCSD Cancer Center
• Latest clinical trials at the University of Texas - MD Anderson Cancer Center