Chronic Lymphocytic Leukemia Research Consortuim
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Research into new ways of treating Chronic Lymphocytic Leukemia is going on all the time. As no current treatments for leukemia cure all the patients treated, doctors dealing with the disease are continually looking for new ways to treat it.

Overview Slides/Movie

A brief set of slides that that introduces the CRC, the centeral mission and introduces each of the projects and core leaders. CLICK HERE to view the movie. Please note that there is NO audio to accompany the slides.

Project 1 - Molecular Genetics of CLL

Carlo M. Croce, M.D.
Ohio State University Cancer Center

Investigates the genetic basis for CLL.

Project 2 - Biochemistry of Apoptosis in CLL

Maurizio Pellecchia, Ph.D.
The Sanford Burnham Medical Research Institute

Varsha Gandhi, Ph.D.
M.D. Anderson Cancer Center

Investigates the leukemia-cell expression of genes and proteins important in the regulation of apoptosis (programmed cell death) and in defining leukemia cell resistance to pharmacologic or biologic therapy.

Project 3 - Immunology

Thomas J. Kipps, M.D., Ph.D.
Moores UCSD Cancer Center

Januario E. Castro, M.D.
Moores UCSD Cancer Center

Michael Choi, M.D.
Moores UCSD Cancer Center

Examines for leukemia-associated antigens and novel techniques for active immunotherapy, including gene therapy.

Project 4 - Immunology and Transplantation

John G. Gribben, D.Sc., F.R.C.P., F.R.C.Path., F.Med.Sci.
Bart's and the London Cancer Center

Examines the potential for adoptive immunotherapy with autologous or allogeneic leukemia-specific T- cells.

Project 5 - Novel Pharmacologic Agents in CLL

William Plunkett, Ph.D.
M.D. Anderson Cancer Center

Peng Huang, M.D., Ph.D.
M.D. Anderson Cancer Center

Examines compounds for Phase I/II testing and their mechanisms of action.

Project 6 - Pharmacology

Amy Johnson, Ph.D.
Ohio State University Cancer Center

John Byrd, M.D.
Ohio State University Cancer Center

Examines for treatment strategies that can achieve remission, and assesses the value of parameters that may serve as prognostic indicators.

Clinical Research Core

William G. Wierda M.D., Ph.D.
M.D. Anderson Cancer Center

Kanti R. Rai, M.D.
North Shore-Long Island Jewish Medical System

Neil E. Kay, M.D.
Mayo Clinic

Jennifer R. Brown, M.D., Ph.D.
Dana-Farber Cancer Institute

Michael J. Keating, M.D., B.S.
M.D. Anderson Cancer Center

Examines for treatment strategies that can achieve remission, and assesses the value of parameters that may serve as prognostic indicators.

Tissue Core

Laura Rassenti, Ph.D.
Moores UCSD Cancer Center

Daniel L. Van Dyke, Ph.D.
Mayo Clinic

Nicholas Chiorazzi, M.D.
North Shore-Long Island Jewish Health System

Provides the necessary infrastructure for all the projects to achieve their potential and expedite their findings.

Biostatistics Core

Donna S. Neuberg, Sc.D.
Dana-Farber Cancer Institute

Provides statistical support for the scientific projects and the cores in the Program Project.

Administrative Core

Thomas J. Kipps, M.D., Ph.D.
Moores UCSD Cancer Center

Andrew W. Greaves
Moores UCSD Cancer Center

Leticia Hu
Sr. Grant Administrator
Moores UCSD Cancer Center

Provides central programmatic leadership and coordination to improve and foster new relationships, to manage future planning, and to facilitate communication between investigators, projects, cores, and other consortium participants. In addition, is responsible for the collection, distribution, and security of clinical data management systems for the entire consortium.


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