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Project 2 - Biochemistry of Apoptosis in CLL

John C. Reed, M.D., Ph.D.
Burnham Institute

B-cell chronic lymphocytic leukemia [B-CLL] is a human neoplastic disorder characterized by the progressive accumulation of small B lymphocytes that appear to be quiescent. We have hypothesized that B-CLL arises primarily because of failures in the normal mechanisms of cell turnover through programmed cell death, rather than as a result of alterations in cell cycle regulation, and that anomalies in the expression and function of apoptosis-regulatory proteins are the critical obstacle to the successful treatment of this malignancy. The overall goal of the biochemistry component of the B-CLL Research Consortium [CRC] is thus to define the fundamental abnormalities of apoptosis regulation in B-CLL, and to devise targeted treatments which address the basic problems.

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