Chronic Lymphocytic Leukemia Research Consortuim
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Research into new ways of treating Chronic Lymphocytic Leukemia is going on all the time. As no current treatments for leukemia cure all the patients treated, doctors dealing with the disease are continually looking for new ways to treat it.

Project 2 - Biochemistry of Apoptosis in CLL

John C. Reed, M.D., Ph.D.
The Burnham Institute


B-cell Chronic Lymphocytic Leukemia [B-CLL] is a human neoplastic disorder characterized by the progressive accumulation of small B-lymphocytes that appear to be quiescent. We have hypothesized that B-CLL arises primarily because of failures in the normal mechanisms of cell turnover through programmed cell death, rather than as a result of alterations in cell cycle regulation, and that anomalies in the expression and function of apoptosis-regulatory proteins are the critical obstacle to the successful treatment of this malignancy. The overall goal of the biochemistry component of the B-CLL Research Consortium [CRC] is thus to define the fundamental abnormalities of apoptosis regulation in B-CLL, and to devise targeted treatments which address the basic problems.


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