Project 3 - Immunology
Project 3 examines novel techniques for active immunotherapy of this disease, including those involving gene transfer.
- Evaluate the mechanism(s) responsible for the acute cytoreduction observed in patients treated with autologous Ad-CD154-transduced CLL cells
- Examine the capacity to generate cellular immune responses against a newly-identified, prototypic CLL-associated antigen, Ror1
- Evaluate anti-leukemia antibodies induced by Ad-CD154 gene therapy
- Evaluate whether the TCL1 mouse model of CLL is a suitable model with which to examine different strategies for AdCD154-gene therapy