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University of California,
San Diego (UCSD)
Rebecca and John Moores UCSD
Cancer Center
La Jolla, CA

Bart's Cancer Centre of
Excellence
Barts Hospital
West Smithfield, London

The Burnham Institute
La Jolla, CA

Dana Farber Cancer Institute
Harvard Medical School
Boston, MA

Long Island Jewish Medical
Center
Division of Hematology/Oncology
New Hyde Park, NY

Mayo Clinic
Rochester, MN

M.D. Anderson Cancer Center
Houston, TX

Ohio State University
Cancer Center
Columbus, Ohio

The CRC

Project	Investigators & Description
Project 1	Molecular Genetics of CLL Carlo Croce, M.D., OSU Cancer Center Investigates the genetic basis for CLL.
Project 2	Biochemistry of Apoptosis in CLL John C. Reed, M.D., Ph.D., Burnham Institute Investigates the leukemia-cell expression of genes and proteins important in the regulation of apoptosis (programmed cell death) and in defining leukemia cell resistance to pharmacologic or biologic therapy.
Projects 3	Immunology Thomas J. Kipps, M.D., Ph.D., Moores UCSD Cancer Center Januario Castro, M.D. Moores UCSD Cancer Center Examines for leukemia-associated antigens and novel techniques for active immunotherapy, including gene therapy.
Project 4	Gene Therapy for CLL John G. Gribben, M.D., Ph.D., Bart's Centre of Excellence Examines the potential for adoptive immunotherapy with autologous or allogeneic leukemia-specific T- cells.
Project 5	Novel Pharmacologic Agents in CLL William Plunkett, Ph.D., M.D. Anderson Cancer Center Varsha Gandhi, Ph.D. M.D. Anderson Cancer Center Peng Huang, Ph.D. M.D. Anderson Cancer Center Examines compounds for Phase I/II testing and their mechanisms of action.
Project 6	Clinical Trials Development Michael R. Grever, M.D., Ohio State University Cancer Center John Byrd, M.D., (Co-Inv) Ohio State University Cancer Center Examines for treatment strategies that can achieve remission, and assesses the value of parameters that may serve as prognostic indicators.
Clinical Research Core	Clinical Trials Development Michael J. Keating, M.D., B.S., M.D. Anderson Cancer Center William Wierda M.D., Ph.D. (Co-Inv) M.D. Anderson Cancer Center Kanti R. Rai, M.D. (Co-Inv) Long Island Jewish Medical Center Neil Kay, M.D., (Co-Inv) Mayo Clinic Susan O'Brien, M.D., (Co-Inv) M.D. Anderson Cancer Center Examines for treatment strategies that can achieve remission, and assesses the value of parameters that may serve as prognostic indicators.
Tissue Core	Laura Rassenti, Ph.D., Moores UCSD Cancer Center Marie Dell’Aquila, Ph.D., Moores UCSD Cancer Center
Biostatistics Core	Donna S. Neuberg, Sc.D., Dana Farber Cancer Institute
Administrative Core	Thomas J. Kipps, M.D., Ph.D., Moores UCSD Cancer Center Andrew W. Greaves Moores UCSD Cancer Center